6-Amino Penicillanic Acid|CAS 551-16-6

The CAS number of 6-Amino Penicillanic Acid is 551-16-6, the solubility in water is very small, the melting point is 208-209 ℃, the appearance is white or slightly yellow crystalline powder. With small inhibitory ability, different side chains can be introduced to obtain a variety of penicillins with different efficacy.6-Amino Penicillanic Acid is an important intermediate in the production of semi-compatible antipenicillin antibiotics ampicillin sodium and amoxicillin. Slightly soluble in water, insoluble in butyl acetate, ethanol or acetone. It is decomposed by alkali and stabilized by acid.

Basic information

English Name: 6-Amino Penicillanic Acid; 6-AMINOPENICILLANIC ACID(6APA)

CAS NO.551-16-6

Molecular Formula: C8H12N2O3S

Molecular weight: 216.26

Properties: white or slightly yellow crystalline powder; odorless or slightly special odor

Solubility: slightly soluble in water, soluble in dilute acid or dilute alkali

Specific optical rotation: +265 °～+285 °

Basic data

Characters：White or Slightly yellow crystalline powder;Odorless or slightly specific odor

Solubility：Slightly soluble in water,Soluble in dilute acid or dilute alkali

Specific Optical Rotation：+265 ° ~+285 °

Specification

PH：3.5～4.5

Water≤0.30%

Absorbance≤0.015

Transmittance≧93.0%

Residual Ethanol≤0.10%

Residual N-butanol≤0.40%

Residual Butyl acetate ≤0.40%

Benzylpenicillin≤ 0.20%

Residual Phenylacetic acid ≤0.40%

Purity≧98.5%

Preparation process

1, the penicillin fermentation broth was concentrated by ultrafiltration membrane separation and nanofiltration membrane concentration to obtain the concentrated filtrate;

2, the concentrated filtrate is placed in a reaction tank, and immobilized penicillin acylase 4MU/m3 concentrated filtrate is added to carry out a conversion reaction to obtain 6-aminopenicillanic acid conversion solution;

3, said conversion liquid is decolorized by activated carbon and filtered to obtain 6-Amino Penicillanic Acid filtrate;

4, to the filtrate described in step c process add crystal seed, raise crystal, crystallization, filtration, washing, drying.